Signalosome
Stephanie Le Coquil
Research Assistant ((AI USPN)
Christine LE-ROY
Deputy Director (CR HDR INSERM)
Syk-signaling
Research Overview
We first investigate the role of Syk kinase as a central node of BCR signaling, testing whether its activation defines a threshold between responder and non-responder patients (C Le Roy et al., Blood, 2012). This axis involves Souleymane Rachidi (PhD), Samar Kabbara (MCF), Stéphanie Le Coquil (ASI), and Antonin Oudar (ASI), combining expertise in signaling analysis, cellular models, and data processing. Using phosphorylation profiling and functional analyses, we aim to identify signaling signatures and potential gain- or loss-of-function variants associated with disease progression. This work is expected to generate predictive biomarkers based on BCR signaling dynamics and to improve patient stratification and monitoring of disease evolution.