Signaling Microenvironment and B Lymphoid Hemopathies
Since 2009, INSERM UMR 1349 SIMHEL develops a translational program on chronic B lymphoid neoplasms, focusing on chronic lymphocytic leukemia and mantle cell lymphoma. Our strategy involves combining fundamental and clinically oriented approaches on signaling mechanisms involved in disease progression. Our aim is to translate our knowledge to the stratification of patients and to new therapeutic options.
Call for applicants for the Inserm chair in cancer research
INSERM invites applications from junior profossorship who wish to manage and lead research teams and participate in national, European or international projects. The position is offered on a fixed-term contract with a view to tenure in the Inserm Research Director personnel at the end of the contract.
Signaling targets in search of societal impact
Beyond translating basic science into European guidelines, our work adds societal value through our knowledge on signaling target, specifically targeting the gap between what guidelines recommend (“ideal practice”) and what happens in the clinic (“realistic best practice”).
“Meaningful research begins with motivation, and failures guide us toward improvement.”
Dominique Ledoux
Professor of Molecular Biology at Sorbonne Paris-Nord University / Vice president for research at the university (2014–2016) / Director of the university’s doctoral school “Sciences, Technologies, Santé-Galilée” (2016–2020)
Highlights
Study of alterations in the communication and activation mechanisms of mast cells and B lymphocytes in ageing and neoplastic diseases. PI (France-Mexico collaboration, 2026–2029, grant ECOS Nord USPN)
Research Assistant ((AI USPN)
Deputy Director (CR HDR INSERM)
Syk-signaling
christine le-roy
Internship
Deputy Director (CR HDR INSERM)
Plasticity: the phd project
Associate Professor (MCF USPN)
Associate Professor (MCF USPN)
Deputy Director (CR HDR INSERM)
CD5 implication
elisabetta dondi
PhD Student
Bioinformatics Scientist (IE INSERM)
Unit Director (DR INSERM)
Research Engineer (IR USPN)
Implication of the lymph node tolerogenic niche in the progression of Chronic Lymphocytic Leukemia (CLL)
Associate Professor (MCF USPN)
Associate Professor (MCU-PH HDR)
Associate Professor (MCF HDR USPN)
Professor (PU-PH)
Unit Director (DR INSERM)
ex-vivo models grant ???, ??? – to date.
Hospital Assistant (AHU)
Professor (PU-PH)
Associate Professor (MCU-PH HDR)
The Phd project We are investigating novel molecular determinants involved in the heterogeneous progression of CLL and in resistance to targeted therapies. To identify new stratification markers grant ???, ??? – to date.
PhD Student
elisabetta dondi
PhD Student
Unit Director (DR INSERM)
The PHD project grant USPN, ??? – to date.
laura gardano
PhD Student
Associate Professor (MCU-PH HDR)
Associate Professor (MCF HDR USPN)
CLL cells are capable to reshape their microenvironment to gain a survival and proliferative advantage. grant USPN, 2025 – to date.
Associate Professor (MCU-PH HDR)
Associate Professor (MCF HDR USPN)
The 3D organisation of the microenvironment can be modelled by spheroids containing CLL cells together with stromal cells and monocytes. These structures allow to study CLL cells dynamics reproducing the architecture and the mechanical constraints of the microenvironment. grant USPN, 2025 – to date.
Deputy Director (CR HDR INSERM)
Professor (PU-PH)
Multimodal Artificial intelligence/Machine Learning and Ontology-Based Predictive Models for Chronic Lymphocytic Leukemia: MIAMO-CLL (Multimodal Modeling of Chronic Lymphocytic Leukemia. PI (grant Infibrex Labex, 2024 - to date).
Bioinformatics Scientist (IE INSERM)
CLL-PID: Familial chronic lymphocytic leukemia and immune deficiencies (grant INCA, 2024 - to date).
claudine irles
PhD Student
claudine irles
Internship
Characterization of endosomal trafficking and BCR activation in leukemic B lymphocytes. PI (2024-2030, grant USPN), collaboration with L. Saveanu (CRI)
