CD5
Denis Lesage
Associate Professor (MCF USPN)
Mélanie Lambert
Associate Professor (MCF USPN)
Christine LE-ROY
Deputy Director (CR HDR INSERM)
CD5 implication
We study CD5 as a functional rheostat of BCR signaling, metabolism, and tumor persistence. We hypothesize that differential CD5 expression modulates the activation threshold of tumor B cells and shapes their metabolic fitness and survival capacity. This project is carried out with PhD students, Melanie Lambert (MCF), Claudine Irles (MCF), Denis Lesage (MCF), Laure Aubard (IE, flow cytometry/cell sorting), and Chuang Dong (IE, bioinformatics), integrating functional immunology, metabolic profiling, flow cytometry, and computational analysis. This approach aims to define functionally distinct tumor subpopulations (CD5low versus CD5high) associated with divergent clinical behavior, with the goal of refining prognostic models and identifying new therapeutic targets linked to cellular metabolism and signaling integration.