Science
Translational and basic research on CLL focuses on three main areas: 1) better defining genetic and functional alterations, particularly with the aim of improving patient stratification and understanding tumor progression; 2) determining the influence of the tumor microenvironment on tumor progression; 3) translational and machine learning models for integrating fundamental and clinical-biological data into preclinical research.
LLC Drivers, Functional Plasticity and Regulatory Mechanisms => Stratification markers
Stromal environment, Tolerogenic environment, Molecular interactions, Metabolism
Established a clinical and biological database => Preclinical studies
Learn more about our research. Research projects
Ongoing projects
Study of alterations in the communication and activation mechanisms of mast cells and B lymphocytes in ageing and neoplastic diseases. PI (France-Mexico collaboration, 2026–2029, grant ECOS Nord USPN)
Research Assistant ((AI USPN)
Deputy Director (CR HDR INSERM)
Syk-signaling
christine le-roy
Internship
Deputy Director (CR HDR INSERM)
Plasticity: the phd project
Associate Professor (MCF USPN)
Associate Professor (MCF USPN)
Deputy Director (CR HDR INSERM)
CD5 implication
elisabetta dondi
PhD Student
Bioinformatics Scientist (IE INSERM)
Unit Director (DR INSERM)
Research Engineer (IR USPN)
Implication of the lymph node tolerogenic niche in the progression of Chronic Lymphocytic Leukemia (CLL)
Associate Professor (MCF USPN)
Associate Professor (MCU-PH HDR)
Associate Professor (MCF HDR USPN)
Professor (PU-PH)
Unit Director (DR INSERM)
ex-vivo models grant ???, ??? – to date.
Hospital Assistant (AHU)
Professor (PU-PH)
Associate Professor (MCU-PH HDR)
The Phd project We are investigating novel molecular determinants involved in the heterogeneous progression of CLL and in resistance to targeted therapies. To identify new stratification markers grant ???, ??? – to date.
PhD Student
elisabetta dondi
PhD Student
Unit Director (DR INSERM)
The PHD project grant USPN, ??? – to date.
laura gardano
PhD Student
Associate Professor (MCU-PH HDR)
Associate Professor (MCF HDR USPN)
CLL cells are capable to reshape their microenvironment to gain a survival and proliferative advantage. grant USPN, 2025 – to date.
Associate Professor (MCU-PH HDR)
Associate Professor (MCF HDR USPN)
The 3D organisation of the microenvironment can be modelled by spheroids containing CLL cells together with stromal cells and monocytes. These structures allow to study CLL cells dynamics reproducing the architecture and the mechanical constraints of the microenvironment. grant USPN, 2025 – to date.
Deputy Director (CR HDR INSERM)
Professor (PU-PH)
Multimodal Artificial intelligence/Machine Learning and Ontology-Based Predictive Models for Chronic Lymphocytic Leukemia: MIAMO-CLL (Multimodal Modeling of Chronic Lymphocytic Leukemia. PI (grant Infibrex Labex, 2024 - to date).
Bioinformatics Scientist (IE INSERM)
CLL-PID: Familial chronic lymphocytic leukemia and immune deficiencies (grant INCA, 2024 - to date).
claudine irles
PhD Student
claudine irles
Internship
Characterization of endosomal trafficking and BCR activation in leukemic B lymphocytes. PI (2024-2030, grant USPN), collaboration with L. Saveanu (CRI)